Saturday, December 14, 2019
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Ticagrelor Is As Effective And Safe As Clopidogrel Post Heart Attack

Ticagrelor Is As Effective And Safe As Clopidogrel Post Heart Attack

Patients provided with clot busters to cure a heart attack fared uniformly well if they were offered with the clopidogrel (standard blood thinning medication) versus the ticagrelor (more potent & newer drug), as per study posted at the 68th Annual Scientific Session of American College of Cardiology.

The test, dubbed as TREAT, is the first international & large test to evaluate ticagrelor’s efficacy and safety in people taking fibrinolytic treatment, or “clot busters,” a set of drugs that fragment the blood clots that lead to heart attacks. Clot busters are employed to cure heart attacks when it is not possible to conduct PCI (percutaneous coronary intervention). PCI is a process to unlock blocked arteries that is the gold measure for curing STEMI (ST-elevation myocardial infarction), the most harsh kind of heart attack. In 2018, scientist claimed that the test met its main endpoint displaying comparable security between clopidogrel and ticagrelor.

On a related note, patients with autoimmune diseases such as lupus, psoriasis, and rheumatoid arthritis are at high jeopardy of getting cardiovascular disease, although none of these symptoms appear to directly aim at the cardiovascular system. Now, scientists in St. Louis at Washington University School of Medicine believe that they have started to recognize the connection between the two.

Scientists experimenting on mice with a psoriasis-akin condition discovered that the blood vessels of mice were stiff. Cholesterol usually flows freely between the tissues and the blood, but the inflexible vessel walls in these mice entrapped cholesterol in their walls, leading to plaques that can result in strokes and heart attacks.

“For years it is been known that the entrapping of cholesterol leads to disease, and now we have a method for how particular immune reactions typical of autoimmune diseases may worsen the case,” claimed Gwendalyn Randolph, senior author of the study and a professor of medicine, to the media in an interview.

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